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Great Dane population genomics
Here is how today's Great Danes are related, how the breed came to be this way, and which dogs would teach us the most if we sequenced them. It starts from pedigree records and aims at the genome. The four pages tell it in order. Start with the map.
1 The MapThe pictureA guided tour of 7,000+ Great Danes by pedigree. How related are they, and how few dogs could we DNA-test to learn about most of the breed?
2 The HistoryHow we got hereSix steps through 140 years of records: two wars, a new continent, inbreeding peaks and new color rules.
3 The EvidenceThe details behind 1 and 2The Kinship Study: methods, numbers and data quality, for anyone who wants to check the work.
4 The PlanWhat we would do about itThe sequencing proposal: which dogs to sequence to preserve the breed’s genetic diversity, with a pilot genome. Working draft.